Ubiquinol (CoQH) is the active form of Ubiquinone (CoQ10). CoQ10 is an extremely popular supplement for all sorts of diseases. It also has a successful history of treating cancer. A typical gel capsule contains 100mg of CoQ10. When you swallow it, only some fraction of it is absorbed. Then once in the blood, your body has to work to convert it to its active (usable) form called ubiquinol. This conversion is very inefficient. It was not until recent years that supplement manufacturers succeeded in finding a way to produce ubiquinol as a supplement. It does not have the same low bioavailability that CoQ10 does, and studies suggest that it may be 8 times as bioavailable as CoQ10 (we will get to liposomal CoQH later on)
The History of CoQ10 as a Successful Cancer Treatment
So let’s first start by seeing what track record CoQ10 has against cancer. Dr. James Howenstine does an excellent job summarizing this:
• “Dr. Folkers followed the course of 6 patients, who had cancer, who were taking CoQ10 for congestive heart failure until 1993. Four of them had lung cancer and 2 had breast cancer. All 6 experienced remissions of cancer thought to be due to CoQ10 therapy. Dr. Folkers recommended the use of 500mg of CoQ daily in patients with malignancies.”
• “Folkers persuaded one of his financial backers, who had developed small cell carcinoma of the lung with widespread metastasis, to try CoQ10 by pointing out that CoQ10 would do no harm and it might help. His oncologist had advised him he had less than a year to live. He began to feel better and had no sign of metastases one year later. Fifteen years after the cancer diagnosis he remained well and free of metastases. The only therapy he received was CoQ10.”
• “In 1980 Dr. Folkers funded a trial of CoQ10 for breast cancer conducted by Dr. Kund Lockwood in Denmark. Dr. Lockwood treated 2 patients with breast cancer one with 300mg of CoQ10 daily and the other with 360mg daily. Both recovered.”
• Dr. Judy found 30 patients with hormone independent prostate cancer and treated them with 500mg. of Coenzyme Q10 daily. Fourteen of the 15 who had no metastases to bone or lung proceeded to have their PSA values return to normal. Of the 15 patients who did have metastases to bone and lung when they started CoQ10, 8 saw their PSA results return to normal suggesting improvement. “
• “Dr. Judy then treated 6 patients with prostate cancer and elevated PSA values with CoQ10 and all 6 had their elevated PSA values return to normal after 120 days of CoQ10 therapy (500 mg.) daily.”
• “Political problems prevented him from publishing these results and Dr. Folkers death in 1998 has terminated all interest in CoQ10 as a therapy for cancer which is unfortunate… The lack of interest in CoQ10 by the pharmaceutical companies as a cancer therapy is caused by their inability to patent it. This should have no effect on patients looking for a safe cancer therapy that seems to work quite well.”
So to summarize these results, at least 37 out of 45 patients with various cancers had apparently positive results. I sincerely doubt many oncologists have even heard of this. These results may not pan out today, as physicians are reporting that therapies used just a couple decades ago (including CoQ10) are not yielding the same results today. Presumably, increasing rates of cancer indicate increasing exposure to environmental causes of cancer. This may also indicate increasing treatment-resistance of cancer.
Though remember that CoQH is possibly many times as effective as CoQ10. You can imagine that the results with CoQH would have done better than CoQ10 had it been studied 20 years ago. The following study seems to confirm that (and maybe even more, since this study was only in the last several years, when cancer is presumably more treatment resistant than in the past):
Study Shows CoQH Is a Useful Cancer Treatment
Kaneka was the original company to manufacture a stable CoQH supplement. They posted a study to their website that was meant to answer general questions about CoQH Ubiquinol and geriatric health. Purely by coincidence, about 40 of the seniors in this study had cancer, and there was a short subgroup analysis on these people described as a “note” in the back pages of this study. This study has now disappeared from the internet, and cannot be found anywhere (that I know of). I only know about this information because my fellow cancer journalist, Pdazzler, read the study before it was removed. Great thanks to him for having found it. One can imagine the paper was taken down due to politics. Kaneka has a printed manual summarizing all sorts of research with ubiquinol and its relevance and treatment ability with many diseases. Looking in the index, there are dozens of conditions listed, some of which I have never heard of. Yet not once in the entire book is the word “cancer” even mentioned.
To the best of my ability, here is a reconstruction of the main points of this study:
• The study lasted 120 days. It involved senior citizens living in four retirement centers in the American Midwest. A total of about 40 of these people coincidentally had various cancers of various stages.
• Pdazzler summarizes the results as follows: “Those cancer patients receiving 100mg of Ubiquinol daily saw a leveling off in their cancer’s progression. Those cancer patients receiving 200mg of Ubiquinol daily saw some reduction in cancer and those cancer patients receiving 400mg of Ubiquinol daily saw a complete regression in their cancers.”
So we are talking about a strong indication of more or less very excellent results in 100% of about 40 patients. As would be expected, these results are even better than the historical results of CoQ10 for the treatment of cancer. It should be noted that perhaps senior citizens may have a tendency to respond better to this therapy than others because they are inherently more deficient in CoQH than younger people (everyone over the age of roughly 25 who does not supplement is to some degree deficient). So these results may be optimistic with regards to the average cancer patient. It should also be noted that this study was not directed at treating cancer, and was not controlled for this aim. I know of at least one cancer patient who did not appear to clearly respond to roughly 60 days of 400mg ubiquinol. Though there is also at least one report of a person remaining stable for the last 6 months, possibly due to 400mg ubiquinol.
But the story doesn’t stop here. Liposomal Ubiquinol (CoQH) might give better results than ordinary ubiquinol.
Liposomal Ubiquinol May Work Even Better
Liposomal encapsulation is a method of drug or nutrient delivery. Virtually any supplement that is either at least somewhat water or fat soluble can be liposomally encapsulated. The result is that these supplements will be likely to give better results clinically.
Phospholipids are a major component of cell membranes. The most common nutritional source of commercially available phospholipids is soy lecithin. Phospholipids have a natural property to break down into nanoscopic (billionths of a meter in size) spheres when sufficiently agitated. These tiny spheres also have a property that they can nicely encase nutrients. Any such nutrient is said to be “liposomally encapsulated”. Liposomal nutrients have at least 11 main benefits over regular nutrients when taken orally:
- The encased nutrients are protected from stomach acid and destruction in the digestive system.
- They may be over 90% absorbed in the intestines. Ordinarily, supplements like vitamin C may be only up to 20% absorbed. Supplements like resveratrol may only be as little as 2% absorbed.
- Once in the bloodstream, they circulate longer and are not as quickly removed by your detoxification organs.
- It is not truly known how liposomes are opened once in the body, but it is believed to happen in at least two ways:
- Liposomes are consumed by phagocytes. This results in the preferential release of the nutrients inside phagocytes. This may be useful when dealing with immuno-modulating supplements that you want to reach macrophages in cancer cases. Though I have not succeeded in verifying this claim, some also claim that phagocytes are found to be more concentrated in tumors than other areas. This would also tend to cause the selective release of liposomally encapsulated nutrients in cancerous tumors. Phagocytes are naturally most abundant in the liver and spleen, meaning liposomal nutrients naturally target these organs as well.
- All cells in your body have phospholipids as a major component of their cell walls. It is believed that the liposomes can “fuse” into cell walls and be used as building blocks for those cell walls. When this happens, the contents of the liposomes are released right beside and/or directly inside cells. This gives liposomes the unique potential of delivering therapeutic agents both inside as well as beside target cells simultaneously.
- It has also been argued that injured cells may be preferentially targeted, as they may have more inclination to “grab” phospholipids to repair their cell walls as compared to healthy cells.
- Liposomes have a more steady and delayed release, as the liposomes are not all opened at once. There is evidence that suggests liposomal supplements can achieve higher plasma concentrations of the encased nutrient(s) for a longer period of time.
- When it comes to cancer, liposomes selectively target cancerous tumors. Cancerous tumors create blood vessels around them that are “diagnostically leaky”. This means that objects have an easier time slipping out of these blood vessels and into surrounding tissue as compared to healthy blood vessels. Well made liposomes are on the order of 50 to 400 nanometers in size. Nanoparticles (of any type) below 200 nanometers in size are believed to be optimal for slipping out of leaky blood vessels with ease, while being too large to easily escape healthy blood vessels. The result is that liposomally encapsulated nutrients can get selectively dumped right into a tumor. This property of liposomes has been well-noticed, and some pharmaceutical chemotherapy drugs utilize this technique. Commercial liposomal supplements are probably in the ballpark of 100 to 400 nanometers in size.
- Liposomes may effectively penetrate bacterial biofilms.
- Liposomes may do a better job crossing the blood-brain-barrier.
- Liposomes may have better penetration into bones
- Liposomal ingredients do not interact with each other in the digestive system
Let’s ignore observations about targeting cancer for a moment, and assess just how much clinical impact liposomally encapsulating a nutrient can give over regular supplementation of the same nutrient. Dr. Thomas Levy has given thousands of high-dose IV Vitamin C treatments, and claims that:
“Taking 4 to 5 grams of liposomal vitamin C is more effective – actually much more effective- than 50 grams of vitamin C intravenously.”
Though anecdotal, this is an actual example from an experienced clinician that argues that small amounts of a liposomal nutrient can outperform even mega doses of that same nutrient given intravenously. Those that follow natural cancer treatment probably know that IV Vitamin C has some history benefiting cancer patients. One might then imagine that liposomal vitamin C could find a real place in cancer treatment. This will be a future topic on the site.
More and more supplements are appearing on the market that have been liposomally encapsulated. These include vitamin C, resveratrol, glutathione, curcumin, ubiquinol, ubiquinone, ashwaganda, selenium, green tea, silibinin (milk thistle), melatonin, vitamin D, vitamin K2, and several others. Just last month, a study was published showing the potential of a liposomal artemisinin supplement. Artemisinin has a history of moderately successful cancer treatment. And since it has poor absorption, liposomally encapsulating it provides special appeal.
Liposomal supplements are starting to get more discussion within the integrative medical world.
So Get to the Liposomal Ubiquinol Already
Now that we have an idea of the potential benefits of liposomes, and an idea at the potential effectiveness of CoQH (ubiquinol) as a cancer therapy, put the two together, and one can realize that the effectiveness of ubiquinol may jump up considerably once liposomally encapsulated. Not to forget that we are dealing with cancer, which also means liposomal ubiquinol will also invoke the additional benefit of selectively targeting tumors. The potential as a cancer therapy here is very impressive in my possibly overzealous opinion.
Recommendations and Where to Buy
In my non-medical opinion, those with cancer should take ubiquinol for the reasons mentioned in this article. If you can afford if, take liposomal ubiquinol over regular ubiquinol. I would take a dosage of 400mg or even 600mg a day.
The cheapest source of liposomal ubiquinol I have found is here:
If you do liposomal ubiquinol at a dose of 400mg a day, it would cost about $4.70 a day. Not all that bad.
If you prefer regular ubiquinol (which I would still strongly encourage), the cost is much cheaper. If you already are pushing your budget on a thorough cancer protocol, this option may be preferable. If you take 600mg a day, the cost is only about $1.70 a day:
These manufacturers are not making any claims about their product. I’m the only psychopath doing that. They might know at least some of what I have written here, but they couldn’t legally say anything even if they did.
Remember to interpret the information in this article using your own intellect. My enthusiasm over the potential of these supplements may not be the only valid viewpoint.
This Is Only Part of the Story
This is only one part of many that would be involved in a comprehensive natural cancer protocol. It is never ever a good idea to depend on just one single supplement. But imagine finding 10 effective natural therapies, any one of which by themselves might save your life (I think I gave away three in this article already). Now imagine the synergy of doing all of them together (provided they are safe and do not interact – which is usually believed to be the case). This is the type of cancer treatment we are moving towards. It is the type of natural cancer treatment that is available now to a minority of educated people, but not widely known, appreciated, or even really legally allowed on a large scale.
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Anyone who is insightful has a meaningful chance of achieving remission in cancer without any toxic therapies. Consider choosing comprehensive natural therapy if you have or get cancer.
Disclaimer: This article contains opinion and is for informational purposes only. It is not to be interpreted as medical advice. If seeking medical advice, consult a licensed physician.
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This entry was posted on Monday, January 17th, 2011 at 6:11 pm.